Synthesis and biological evaluation of novel N-α-haloacylated homoserine lactones as quorum sensing modulators

• Michail Syrpas,
• Ewout Ruysbergh,
• Christian V. Stevens,
• Norbert De Kimpe and
• Sven Mangelinckx

Beilstein J. Org. Chem. 2014, 10, 2539–2549, doi:10.3762/bjoc.10.265

• Michail Syrpas Ewout Ruysbergh Christian V. Stevens Norbert De Kimpe Sven Mangelinckx Department of Sustainable Organic Chemistry and Technology, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium 10.3762/bjoc.10.265 Abstract Novel N-α-haloacylated homoserine lactones, in which a halogen

• ; N-α-haloacylated homoserine lactones; quorum sensing; Introduction Quorum sensing (QS) is the communication system used by bacteria allowing them to adapt to their environment [1]. Bacteria relying on QS secrete signal molecules, called autoinducers, in order to control the expression of specific

• influence of a halogen introduction, the bioactivity of these novel N-α-haloacylated homoserine lactones was directly compared with a broad library of naturally occurring AHLs. Results and Discussion Synthesis of N-acylated homoserine lactones and halogenated analogues (S)-Homoserine lactone hydrobromide (1